Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TPMT | P51580 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7394590 | 0.92 | TPMT (0.41) | HSD17B10KDM4EALDH1A1MEN1HTT | |
| SCHEMBL7415790 | 0.88 | PARP1 (0.43) | HSD17B10KDM4EALDH1A1MEN1HTT | |
| SCHEMBL7307695 | 0.81 | HSD17B10 (0.41) | HSD17B10KDM4EALDH1A1MEN1HTT | |
| SCHEMBL7387703 | 0.77 | LMNA (0.39) | HSD17B10KDM4EALDH1A1MEN1HTT | |
| SCHEMBL7407896 | 0.77 | ADRA2A (0.52) | KDM4EALDH1A1TSHRLMNAACHE | |
| SCHEMBL7318609 | 0.75 | HSD17B10 (0.36) | HSD17B10KDM4EALDH1A1MEN1HTT | |
| SCHEMBL7408559 | 0.72 | HTR3A (0.59) | MEN1KMT2A | |
| SCHEMBL3950495 | 0.71 | ALDH1A1 (0.49) | HSD17B10KDM4EALDH1A1MEN1HTT | |
| SCHEMBL13312001 | 0.69 | PARP1 (0.43) | HSD17B10KDM4EALDH1A1MEN1HTT | |
| SCHEMBL7331519 | 0.69 | PPARA (0.36) | HSD17B10KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5063230-A | Substituted saturated and unsaturated indole quinoline and benzazepine carboxamides and their use as pharmacological agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-11-05 | — | — | US | disclosed |
| WO-1990006113-A1 | SUBSTITUTED SATURATED AND UNSATURATED INDOLE QUINOLINE AND BENZAZEPINE CARBOXAMIDES AND THEIR USE AS PHARMACOLOGICAL AGENTS | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1990-06-14 | — | — | WO | disclosed |
| US-4920219-A | Substituted saturated and unsaturated indole quinoline and benzazepine carboxamides and their use as pharmacological agents | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |