Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TPMT | P51580 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109690 | 0.98 | TSHR (0.60) | TSHRTP53SRD5A2CA1CA2 | |
| SCHEMBL240289 | 0.89 | TSHR (0.50) | TSHRTP53SRD5A2CA1CA2 | |
| Hydrochloric Acid SCHEMBL10981830 | 0.79 | PARP10 (0.46) | TSHRCA1CA2CA12CA9 | |
| Terephthalic Acid SCHEMBL5014892 | 0.79 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 | |
| SCHEMBL111501 | 0.77 | ALDH1A1 (0.61) | TSHRTP53SRD5A2ALDH1A1ALOX15 | |
| SCHEMBL6260247 | 0.76 | PARP10 (0.48) | TSHRCA1CA2CA12CA9 | |
| Hydrochloric Acid SCHEMBL11584405 | 0.76 | CA12 (0.42) | TSHRTP53CA1CA2CA12 | |
| Terephthalic Acid SCHEMBL25175830 | 0.76 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL31248123 | 0.76 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL29224800 | 0.76 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8784980-B2 | Film prepared from a casting composition comprising a polymer and surface modified hexagonal boron nitride particles | E I DU PONT DE NEMOURS AND COMPANY (US) | 2014-07-22 | — | — | US | disclosed |
| CN-102421701-B | Surface modified hexagonal boron nitride particles | DU PONT | 2014-07-16 | — | — | CN | disclosed |
| CN-102421829-B | A film prepared from a casting composition comprising a polymer and surface modified hexagonal boron nitride particles | DU PONT | 2014-05-07 | — | — | CN | disclosed |
| CN-102421841-B | Composite of polymer and surface modified hexagonal boron nitride particles | DU PONT | 2014-04-09 | — | — | CN | disclosed |
| US-8440292-B2 | Multi-layer article for flexible printed circuits | E I DU PONT DE NEMOURS AND COMPANY (US) | 2013-05-14 | — | — | US | disclosed |
| US-8314215-B2 | Mild chemically cleavable linker system | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2012-11-20 | — | — | US | disclosed |
| US-8288466-B2 | Composite of a polymer and surface modified hexagonal boron nitride particles | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-10-16 | — | — | US | disclosed |
| US-8258346-B2 | Surface modified hexagonal boron nitride particles | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-09-04 | — | — | US | disclosed |
| CN-102421829-A | Films made from casting compositions comprising polymer and surface modified hexagonal boron nitride particles | DU PONT | 2012-04-18 | — | — | CN | disclosed |
| CN-102421701-A | Surface modified hexagonal boron nitride particles | DU PONT | 2012-04-18 | — | — | CN | disclosed |
| US-20100288968-A1 | COMPOSITE OF A POLYMER AND SURFACE MODIFIED HEXAGONAL BORON NITRIDE PARTICLES | E. I. DU PONT DE NEMOURS AND COMPANY (DE) | 2010-11-18 | — | — | US | disclosed |
| WO-2010132512-A2 | SURFACE MODIFIED HEXAGONAL BORON NITRIDE PARTICLES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-11-18 | — | — | WO | disclosed |
| WO-2010132510-A2 | COMPOSITE OF A POLYMER AND SURFACE MODIFIED HEXAGONAL BORON NITRIDE PARTICLES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-11-18 | — | — | WO | disclosed |
| US-20100291365-A1 | FILM PREPARED FROM A CASTING COMPOSITION COMPRISING A POLYMER AND SURFACE MODIFIED HEXAGONAL BORON NITRIDE PARTICLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-11-18 | — | — | US | disclosed |
| WO-2010132519-A2 | A FILM PREPARED FROM A CASTING COMPOSITION COMPRISING A POLYMER AND SURFACE MODIFIED HEXAGONAL BORON NITRIDE PARTICLES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-11-18 | — | — | WO | disclosed |
| US-20100292508-A1 | SURFACE MODIFIED HEXAGONAL BORON NITRIDE PARTICLES | E. I. DU POND DE NEMOURS AND COMPANY (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100291371-A1 | MULTI-LAYER ARTICLE FOR FLEXIBLE PRINTED CIRCUITS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100003735-A1 | Mild Chemically Cleavable Linker System | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2010-01-07 | — | — | US | disclosed |
| WO-2008094205-A2 | A MILD CHEMICALLY CLEAVABLE LINKER SYSTEM | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2008-08-07 | — | — | WO | disclosed |
| US-4094964-A | IMMUNOASSAY, HAPTEN, ANTIGEN | HOFFMANN-LA ROCHE INC. (US) | 1978-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003735-A1 | Mild Chemically Cleavable Linker System | BTD, SPR, DDO | TSHR 1387/4885TP53 2054/4885SRD5A2 3112/4885 |
| US-20100292508-A1 | SURFACE MODIFIED HEXAGONAL BORON NITRIDE PARTICLES | SHROOM3, HAO2, NOXO1 | TSHR 895/4885TP53 3026/4885SRD5A2 2976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.