Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LIPE | Q05469 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6790329 | 0.89 | SMN1; SMN2 (0.59) | SMN1; SMN2LIPEALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7288147 | 0.76 | CPA1 (0.53) | SMN1; SMN2ALDH1A1CYP1A2HTTUSP2 | |
| Benzenemethanethiol SCHEMBL7371355 | 0.76 | USP2 (0.46) | SMN1; SMN2LIPEALDH1A1CYP2C19HTT | |
| SCHEMBL7445195 | 0.75 | LIPE (0.63) | LIPEALDH1A1HTTUSP2MAPT | |
| SCHEMBL7287469 | 0.75 | LIPE (0.46) | SMN1; SMN2LIPEALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9503176 | 0.75 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1CYP2C19NPC1RAB9A | |
| SCHEMBL7701320 | 0.74 | KMT2A (0.58) | SMN1; SMN2ALDH1A1HTTNPC1RAB9A | |
| SCHEMBL27696449 | 0.73 | HTT (0.57) | SMN1; SMN2ALDH1A1HTTNPC1RAB9A | |
| SCHEMBL7536026 | 0.73 | MMP8 (0.45) | SMN1; SMN2LIPEALDH1A1CYP1A2HTT | |
| SCHEMBL7536033 | 0.73 | MMP8 (0.45) | SMN1; SMN2LIPEALDH1A1CYP1A2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117840-A | INHIBITS BINDING BETWEEN VLA-4 RECEPTOR EXPRESSED ON INFLAMMATORY LEUKOCYTES AND FIBRONECTIN CS-1 PEPTIDE EXPRESSED ON ENDOTHELIAL CELLS THAT ARE INVOLVED IN IMMUNOINFLAMMATORY DISEASE STATES | CYTEL CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
| WO-2000002903-A1 | CS-1 PEPTIDOMIMETICS, COMPOSITIONS AND METHODS OF USING THE SAME | CYTEL CORPORATION (US) | 2000-01-20 | — | — | WO | disclosed |
| US-5936065-A | PRODRUG AS ANTIINFLAMMATORY AGENT FOR AUTOIMMUNE DISEASES; FOR SUPPRESSING BINDING OF INFLAMMATORY CELLS TO ENDOTHELIAL CELLS THAT EXPRESS THE CS-1 PORTION OF FIBRONECTIN ON THEIR SURFACES | CYTEL CORPORATION (US) | 1999-08-10 | — | — | US | disclosed |
| US-5821231-A | TREATMENT OF IMMUNOINFLAMMATORY CONDITIONS | CYTEL CORPORATION (US) | 1998-10-13 | — | — | US | disclosed |
| US-5770573-A | CS-1 peptidomimetics, compositions and methods of using the same | CYTEL CORPORATION (US) | 1998-06-23 | — | — | US | disclosed |
| US-5688913-A | OLIGOPEPTIDES AS ANTIINFLAMMATORY AGENTS | CYTEL CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |