Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.47 |
| ▸ | MMP12 | P39900 | 6/20 | 0.47 |
| ▸ | MMP13 | P45452 | 6/20 | 0.47 |
| ▸ | MMP14 | P50281 | 6/20 | 0.47 |
| ▸ | MMP8 | P22894 | 4/20 | 0.47 |
| ▸ | MMP16 | P51512 | 4/20 | 0.47 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 5/20 | 0.45 |
| ▸ | MMP1 | P03956 | 4/20 | 0.45 |
| ▸ | MMP3 | P08254 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7417562 | 0.83 | TP53 (0.42) | L3MBTL1PTGDR2LMNAMAPK1RAB9A | |
| SCHEMBL8058697 | 0.79 | HTR6 (0.46) | L3MBTL1LMNAMAPK1RAB9AALDH1A1 | |
| SCHEMBL7414743 | 0.79 | HTT (0.53) | PTGDR2LMNAALDH1A1 | |
| SCHEMBL1628791 | 0.76 | L3MBTL1 (0.62) | L3MBTL1GLAALDH1A1 | |
| Hydrochloric Acid SCHEMBL2525349 | 0.75 | L3MBTL1 (0.61) | L3MBTL1GLAALDH1A1 | |
| SCHEMBL23229170 | 0.74 | HSD17B10 (0.51) | L3MBTL1GLAPTGDR2MAPK1HSD17B10 | |
| SCHEMBL17967503 | 0.73 | HSD17B10 (0.77) | LMNAMAPK1HSD17B10 | |
| SCHEMBL20847652 | 0.71 | MEN1 (0.66) | SQSTM1KEAP1NFE2L2L3MBTL1MAPK1 | |
| SCHEMBL1982527 | 0.71 | APEX1 (0.52) | L3MBTL1APEX1LMNAALDH1A1 | |
| SCHEMBL9899219 | 0.70 | GLA (0.46) | L3MBTL1GLALMNAMAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163214-A1 | GAMMA-KETOACID DIPEPTIDES AS INHIBITORS OF CASPASE-3 | Merck Frosst Canada & Co. (CA) | 2001-12-19 | — | — | EP | disclosed |
| US-6225288-B1 | IMPLICATED IN MODULATING APOPTOSIS; TREATMENT OF:CARDIAC AND CEREBRAL ISCHEMIA/REPERFUSION INJURY, SPINAL CORD INJURY AND ORGAN DAMAGE DURING TRANSPLANTATION, CHRONIC NEURODEGENERATIVE DISEASES, IMMUNODEFICIENCY, DIABETES, ALOPECIA, AGING | MERK FROSST CANADA & CO. (CA) | 2001-05-01 | — | — | US | disclosed |
| WO-2000055127-A1 | GAMMA-KETOACID DIPEPTIDES AS INHIBITORS OF CASPASE-3 | MERCK FROSST CANADA & CO. (CA) | 2000-09-21 | — | — | WO | disclosed |