Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7421793 | 0.83 | NPC1 (0.50) | SMN1; SMN2MAPTKDM4EALDH1A1HTT | |
| SCHEMBL6009689 | 0.73 | TDP1 (0.61) | TDP1POLBL3MBTL1GAACYP3A4 | |
| SCHEMBL7414529 | 0.73 | POLB (0.40) | SMN1; SMN2TDP1POLBL3MBTL1ALDH1A1 | |
| SCHEMBL9824905 | 0.71 | POLB (0.51) | SMN1; SMN2TDP1POLBL3MBTL1ALDH1A1 | |
| SCHEMBL13678990 | 0.71 | EPHX2 (0.45) | SMN1; SMN2TDP1POLBALDH1A1RAB9A | |
| SCHEMBL13220228 | 0.69 | ALDH1A1 (0.69) | SMN1; SMN2ALDH1A1KMT2ALMNA | |
| N',N'-Dimethylbenzohydrazide SCHEMBL952727 | 0.69 | POLB (0.56) | SMN1; SMN2TDP1MAPTKDM4EPOLB | |
| SCHEMBL9799560 | 0.69 | TSHR (0.63) | SMN1; SMN2TDP1MAPTKDM4EPOLB | |
| SCHEMBL2026026 | 0.69 | TSHR (0.63) | SMN1; SMN2TDP1MAPTKDM4EPOLB | |
| Hippuric Acid SCHEMBL2597829 | 0.69 | GPR139 (0.55) | SMN1; SMN2TDP1MAPTKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218389-B1 | FOR THERAPY AND PROPHYLAXIS OF ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS; SKIN DISORDERS; OCULAR DISORDERS; INFLAMMATION AND GUM DISEASES, MULTIPLE SCLEROSIS, CACHEXIA, PREVENTING LOOSENING OF PROSTHETIC DEVICES | THE PROCTER & GAMBLE CO. | 2001-04-17 | — | — | US | disclosed |
| CN-1265647-A | Acyclic metalloprotease inhibitors | PROCTER & GAMBLE (US) | 2000-09-06 | — | — | CN | disclosed |
| EP-1009737-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999006340-A2 | SULFONYLAMINO SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-02-11 | — | — | WO | disclosed |