Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416446 | 0.79 | GLA (0.47) | MEN1KMT2ANPC1L3MBTL1GLA | |
| SCHEMBL8047365 | 0.72 | ALDH1A1 (0.50) | KMT2AL3MBTL1GLAPTPRCCTDSP1 | |
| SCHEMBL27890273 | 0.72 | ALDH1A1 (0.50) | KMT2AL3MBTL1GLAPTPRCCTDSP1 | |
| SCHEMBL18247354 | 0.70 | HTR6 (0.66) | MEN1KMT2ANPC1L3MBTL1GLA | |
| Hydrochloric Acid SCHEMBL8053961 | 0.69 | ADRA1D (0.47) | MEN1KMT2AL3MBTL1GLAALDH1A1 | |
| SCHEMBL28023638 | 0.69 | PSIP1 (0.50) | ALDH1A1MAPTPSIP1ATMHSD17B10 | |
| SCHEMBL254754 | 0.68 | ALDH1A1 (0.54) | MEN1KMT2AL3MBTL1GLACTDSP1 | |
| SCHEMBL9197961 | 0.68 | HTR6 (0.44) | ALDH1A1MAPTPSIP1HSD17B10TDP1 | |
| SCHEMBL11603748 | 0.68 | ALDH1A1 (0.54) | KMT2AL3MBTL1GLAPTPRCCTDSP1 | |
| SCHEMBL9127430 | 0.68 | L3MBTL1 (0.49) | MEN1KMT2ANPC1L3MBTL1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1163214-A1 | GAMMA-KETOACID DIPEPTIDES AS INHIBITORS OF CASPASE-3 | Merck Frosst Canada & Co. (CA) | 2001-12-19 | — | — | EP | disclosed |
| US-6225288-B1 | IMPLICATED IN MODULATING APOPTOSIS; TREATMENT OF:CARDIAC AND CEREBRAL ISCHEMIA/REPERFUSION INJURY, SPINAL CORD INJURY AND ORGAN DAMAGE DURING TRANSPLANTATION, CHRONIC NEURODEGENERATIVE DISEASES, IMMUNODEFICIENCY, DIABETES, ALOPECIA, AGING | MERK FROSST CANADA & CO. (CA) | 2001-05-01 | — | — | US | disclosed |
| WO-2000055127-A1 | GAMMA-KETOACID DIPEPTIDES AS INHIBITORS OF CASPASE-3 | MERCK FROSST CANADA & CO. (CA) | 2000-09-21 | — | — | WO | disclosed |