Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7699241 | 0.93 | F2 (0.39) | ALDH1A1MAPTF2TMPRSS6L3MBTL1 | |
| SCHEMBL7415235 | 0.93 | KCNA5 (0.44) | F2TMPRSS6L3MBTL1ITGB3ITGA2B | |
| SCHEMBL7416574 | 0.92 | ITGB3 (0.45) | F2TMPRSS6L3MBTL1ITGB3ITGA2B | |
| SCHEMBL7694791 | 0.92 | MMP2 (0.45) | F2TMPRSS6ITGB3ITGA2BADAMTS4 | |
| SCHEMBL7699209 | 0.91 | F2 (0.42) | F2TMPRSS6L3MBTL1ITGB3ITGA2B | |
| SCHEMBL7418524 | 0.90 | F2 (0.43) | ALDH1A1F2TMPRSS6ITGB3ITGA2B | |
| SCHEMBL7413464 | 0.90 | F2 (0.42) | F2TMPRSS6L3MBTL1ITGB3ITGA2B | |
| SCHEMBL7412629 | 0.90 | CTSL (0.43) | F2TMPRSS6L3MBTL1ITGB3ITGA2B | |
| SCHEMBL7414434 | 0.90 | F2 (0.42) | ALDH1A1F2TMPRSS6L3MBTL1ITGB3 | |
| SCHEMBL7417592 | 0.90 | ITGB3 (0.49) | F2TMPRSS6ITGB3ITGA2BMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344484-B1 | TREATMENT OF TUMOR GROWTH, METASTASIS, OSTEOPOROSIS, RESTENOSIS, INFLAMMATION, MACULAR DEGENERATION, DIABETIC RETINOPATHY, AND RHEUMATOID ARTHRITIS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-02-05 | — | — | US | disclosed |
| EP-1159262-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000047552-A1 | TYROSINE ALKOXYGUANIDINES AS INTEGRIN INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | disclosed |