Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 1/20 | 0.44 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.44 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 7/20 | 0.42 |
| ▸ | RAB9A | P51151 | 7/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416926 | 0.79 | MAPT (0.50) | PLOD2PLOD3PLOD1ALDH1A1NPC1 | |
| SCHEMBL7416558 | 0.78 | ALDH1A1 (0.53) | PLOD2HDAC1ALDH1A1KMT2ALMNA | |
| SCHEMBL7413719 | 0.77 | F7 (0.47) | PLOD2HDAC1ALDH1A1KMT2ATSHR | |
| SCHEMBL7418585 | 0.74 | PLOD2 (0.39) | PLOD2PLOD3PLOD1HDAC1ALDH1A1 | |
| SCHEMBL22920041 | 0.73 | L3MBTL1 (0.60) | ALDH1A1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL7412060 | 0.73 | MAPT (0.55) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL28059851 | 0.72 | AKR1C1 (0.53) | PLOD2ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL12977958 | 0.68 | TRPV1 (0.54) | NPC1RAB9ASMN1; SMN2KMT2AABL1 | |
| SCHEMBL7415701 | 0.68 | HDAC1 (0.41) | HDAC1ALDH1A1SMN1; SMN2TSHR | |
| SCHEMBL11161284 | 0.68 | ROCK2 (0.66) | ROCK2ROCK1ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095025-B1 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2002-12-11 | — | — | EP | disclosed |
| US-6248770-B1 | CARDIOVASCULAR DISORDERS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-06-19 | — | — | US | disclosed |
| EP-1095025-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM KG (DE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001704-A2 | BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-01-13 | — | — | WO | disclosed |