Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 3/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423535 | 0.88 | SMN1; SMN2 (0.44) | GRNSORT1MAPK1MEN1KMT2A | |
| SCHEMBL7425540 | 0.86 | DGAT1 (0.47) | MEN1KMT2APOLBALDH1A1NR1H4 | |
| SCHEMBL7419482 | 0.83 | GRN (0.49) | GRNSORT1MAPK1POLBALDH1A1 | |
| SCHEMBL7419023 | 0.81 | GRN (0.47) | GRNSORT1MAPK1POLBKDM4E | |
| SCHEMBL7426474 | 0.80 | GRIA2 (0.52) | GRNSORT1MEN1KMT2AMAPT | |
| SCHEMBL7427045 | 0.80 | GRIA2 (0.52) | GRNSORT1MEN1KMT2AMAPT | |
| SCHEMBL7425053 | 0.80 | CA2 (0.50) | GRNSORT1MEN1KMT2ACA2 | |
| SCHEMBL7428201 | 0.80 | GRN (0.46) | GRNSORT1MAPK1MAPTALDH1A1 | |
| SCHEMBL7424624 | 0.80 | GRN (0.44) | GRNSORT1MAPK1MEN1KMT2A | |
| SCHEMBL5869935 | 0.78 | GRN (0.52) | GRNSORT1MAPK1CA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |