Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 4/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.36 |
| ▸ | ACE | P12821 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7423140 | 0.87 | CTSS (0.48) | ALDH1A1MAPTCTSLCTSSCTSK | |
| SCHEMBL7429170 | 0.86 | ALDH1A1 (0.46) | ALDH1A1MAPTCTSLCTSSCTSK | |
| SCHEMBL7424624 | 0.86 | GRN (0.44) | GRNSORT1ALDH1A1MAPK1MAPT | |
| SCHEMBL7419482 | 0.85 | GRN (0.49) | GRNSORT1ALDH1A1MAPK1LMNA | |
| SCHEMBL7426514 | 0.85 | ALDH1A1 (0.46) | ALDH1A1MAPTCTSLCTSSCTSK | |
| SCHEMBL7419023 | 0.83 | GRN (0.47) | GRNSORT1ALDH1A1MAPK1LMNA | |
| SCHEMBL7422452 | 0.81 | GRN (0.44) | GRNSORT1ALDH1A1MAPK1LMNA | |
| SCHEMBL7426644 | 0.80 | GRN (0.50) | GRNSORT1ALDH1A1MAPK1MAPT | |
| SCHEMBL7422599 | 0.78 | GRN (0.47) | GRNSORT1ALDH1A1MAPK1LMNA | |
| SCHEMBL7417901 | 0.78 | FOLH1 (0.57) | GRNSORT1ALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |