Sugi Predict

Sugi Predict / Compounds / SCHEMBL741955

SCHEMBL741955

SCHEMBL741955

COC(=O)c1cc2cc(Cl)c(F)cc2[nH]1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALPL P05186 2/20 0.52
▸ XDH P47989 3/20 0.47
▸ ALOX15 P16050 3/20 0.43
▸ PYGL P06737 1/20 0.43
▸ CYP1A2 P05177 1/20 0.41
▸ EIF4A3 P38919 1/20 0.41
▸ MAPT P10636 3/20 0.40
▸ KDM4E B2RXH2 2/20 0.40
▸ ALDH1A1 P00352 2/20 0.40
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ NPC1 O15118 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ GLA P06280 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ HPGD P15428 1/20 0.40
▸ RAB9A P51151 1/20 0.40
▸ ATM Q13315 1/20 0.40
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ ABL1 P00519 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30310681 0.94 ALPL (0.52) ALPLXDHALOX15CYP1A2EIF4A3
SCHEMBL1307049 0.94 ALPL (0.52) ALPLXDHALOX15CYP1A2EIF4A3
SCHEMBL16235851 0.87 XDH (0.51) ALPLXDHCYP1A2EIF4A3MAPT
SCHEMBL31219118 0.87 XDH (0.51) ALPLXDHCYP1A2EIF4A3MAPT
SCHEMBL4395738 0.84 ALOX15 (0.63) ALOX15MAPTKDM4EALDH1A1MEN1
SCHEMBL832561 0.83 XDH (0.48) ALPLXDHALOX15CYP1A2EIF4A3
SCHEMBL18824232 0.82 POLB (0.48) XDHALOX15CYP1A2MAPTKDM4E
SCHEMBL24740104 0.81 ALOX15 (0.63) ALPLALOX15PYGLEIF4A3MAPT
SCHEMBL741404 0.81 EIF4A3 (0.56) ALPLALOX15PYGLCYP1A2EIF4A3
SCHEMBL384853 0.81 XDH (0.47) ALPLXDHALOX15CYP1A2EIF4A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250302842-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR TREATMENT OF CANCERS Jubilant Epipad LLC 2025-10-02 — — US disclosed
US-12357639-B2 Heterocyclic compounds as pad inhibitors Jubilant Epipad LLC (US) 2025-07-15 — — US disclosed
US-20240156831-A1 HETEROCYCLIC COMPOUNDS AS PAD INHIBITORS Jubilant Epipad LLC 2024-05-16 — — US disclosed
EP-3684767-B1 HETEROCYCLIC COMPOUNDS AS PAD INHIBITORS Jubilant Epipad LLC (US) 2024-04-24 — — EP disclosed
EP-3684767-B1 HETEROCYCLIC COMPOUNDS AS PAD INHIBITORS Jubilant Epipad LLC (US) 2024-04-24 — — EP disclosed
US-11833156-B2 Heterocyclic compounds as pad inhibitors Jubilant Epipad LLC (US) 2023-12-05 — — US disclosed
US-11833156-B2 Heterocyclic compounds as pad inhibitors Jubilant Epipad LLC (US) 2023-12-05 — — US disclosed
US-11833156-B2 Heterocyclic compounds as pad inhibitors Jubilant Epipad LLC (US) 2023-12-05 — — US disclosed
CN-111108105-B Heterocyclic compounds as PAD inhibitors 朱比兰特埃皮帕德有限公司 2023-03-31 — — CN disclosed
US-20200276206-A1 HETEROCYCLIC COMPOUNDS AS PAD INHIBITORS Jubilant Epipad LLC 2020-09-03 — — US disclosed
US-20060004009-A1 Ethylenediamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-01-05 — — US disclosed
US-20050245565-A1 Diamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2005-11-03 — — US disclosed
EP-1577301-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2005-09-21 — — EP disclosed
US-20050119486-A1 Diamine derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2005-06-02 — — US disclosed
US-20050020645-A1 Diamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2005-01-27 — — US disclosed
US-20040122063-A1 Ethylenediamine derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-06-24 — — US disclosed
EP-1415992-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-05-06 — — EP disclosed
EP-1405852-A1 DIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2004-04-07 — — EP disclosed
EP-1270557-A1 ETHYLENEDIAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2003-01-02 — — EP disclosed
US-5494928-A FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS HOFFMANN-LA ROCHE INC. (US) 1996-02-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11833156-B2 Heterocyclic compounds as pad inhibitors PADI4, PADI2, PADI1 ALPL 3070/4885XDH 75/4885ALOX15 770/4885
US-20250302842-A1 HETEROCYCLIC COMPOUNDS USEFUL FOR TREATMENT OF CANCERS NES, VHL, ETV6 ALPL 818/4885XDH 2820/4885ALOX15 2853/4885
US-20060004009-A1 Ethylenediamine derivatives F2, ECE1, MLLT1 ALPL 4835/4885XDH 855/4885ALOX15 2113/4885
US-20240156831-A1 HETEROCYCLIC COMPOUNDS AS PAD INHIBITORS PADI4, PADI2, PADI1 ALPL 1985/4885XDH 154/4885ALOX15 2364/4885
US-20200276206-A1 HETEROCYCLIC COMPOUNDS AS PAD INHIBITORS PADI4, PADI2, PADI1 ALPL 3070/4885XDH 75/4885ALOX15 770/4885
US-20050020645-A1 Diamine derivatives C9, C1S, C1R ALPL 4358/4885XDH 2302/4885ALOX15 872/4885
US-20050245565-A1 Diamine derivatives C9, C1S, C1R ALPL 4358/4885XDH 2302/4885ALOX15 872/4885
US-20050119486-A1 Diamine derivatives C9, C1S, C1R ALPL 4358/4885XDH 2302/4885ALOX15 872/4885
US-12357639-B2 Heterocyclic compounds as pad inhibitors PADI4, PADI2, PADI1 ALPL 1985/4885XDH 154/4885ALOX15 2364/4885
US-20040122063-A1 Ethylenediamine derivatives ECE1, F2, ECE2 ALPL 4821/4885XDH 1028/4885ALOX15 2424/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.