Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7419892 | 1.00 | LMNA (0.34) | LMNAHSD17B10CA1CA12CA7 | |
| SCHEMBL18884435 | 0.77 | LMNA (0.38) | LMNAHSD17B10CA1ALDH1A1CA2 | |
| SCHEMBL18878199 | 0.75 | DGAT1 (0.35) | LMNAHSD17B10CA1CA12CA7 | |
| SCHEMBL22838156 | 0.73 | ELANE (0.35) | LMNAHSD17B10CA1ALDH1A1CA2 | |
| SCHEMBL28382469 | 0.71 | LMNA (0.38) | LMNAHSD17B10ALDH1A1DGAT1 | |
| SCHEMBL7330484 | 0.70 | CA12 (0.33) | LMNAHSD17B10CA1CA12CA7 | |
| SCHEMBL16222807 | 0.70 | ALDH1A1 (0.36) | LMNAHSD17B10ALDH1A1DGAT1 | |
| SCHEMBL14562924 | 0.70 | ALDH1A1 (0.36) | LMNAHSD17B10ALDH1A1DGAT1 | |
| SCHEMBL21300545 | 0.70 | CA1 (0.38) | CA1CA12CA14ALDH1A1CA2 | |
| SCHEMBL9243513 | 0.69 | DGAT1 (0.41) | LMNAHSD17B10CA1ALDH1A1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0801648-A4 | SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-01-28 | — | — | EP | disclosed |
| EP-0801648-A1 | SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1997-10-22 | — | — | EP | disclosed |
| US-5556909-A | PROTEOLYTIC ENZYME INHIBITOR, TREATMENT OF DEGENERATIVE DISEASES, SUCH AS EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI WINTHROP INC. (US) | 1996-09-17 | — | — | US | disclosed |
| WO-1996016951-A1 | SUBSTITUTED 2-ARYLCARBONYLOXYMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDE DERIVATIVES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-06-06 | — | — | WO | disclosed |