Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 14/20 | 0.41 |
| ▸ | MMP1 | P03956 | 14/20 | 0.41 |
| ▸ | MMP9 | P14780 | 13/20 | 0.41 |
| ▸ | MMP2 | P08253 | 9/20 | 0.41 |
| ▸ | MMP8 | P22894 | 5/20 | 0.41 |
| ▸ | MMP7 | P09237 | 7/20 | 0.41 |
| ▸ | MMP13 | P45452 | 9/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6075460 | 0.98 | MMP1 (0.43) | MMP3MMP1MMP9MMP2MMP8 | |
| SCHEMBL6075492 | 0.93 | MMP1 (0.45) | MMP3MMP1MMP9MMP2MMP8 | |
| SCHEMBL6075584 | 0.85 | ALDH1A1 (0.42) | MMP3MMP1MMP9MMP2MMP8 | |
| SCHEMBL6075466 | 0.83 | PKM (0.47) | MMP3MMP1MMP9MMP2MMP8 | |
| SCHEMBL6076121 | 0.83 | MMP3 (0.46) | MMP3MMP1MMP9MMP2MMP8 | |
| SCHEMBL6075809 | 0.83 | MMP9 (0.43) | MMP3MMP1MMP9MMP2MMP8 | |
| SCHEMBL6075926 | 0.82 | CHRM5 (0.44) | MMP3MMP1MMP9MMP2MMP8 | |
| SCHEMBL6075423 | 0.80 | MMP1 (0.45) | MMP3MMP1MMP9MMP2MMP8 | |
| SCHEMBL6076042 | 0.80 | CA12 (0.53) | MMP3MMP1MMP9MMP2MMP7 | |
| SCHEMBL7423274 | 0.79 | MMP9 (0.40) | MMP3MMP1MMP9MMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040099-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | Amgen Inc., (US) | 2000-10-04 | — | — | EP | disclosed |
| WO-1999032451-A1 | AZEPINE OR LARGER MEDIUM RING DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | AMGEN INC. (US) | 1999-07-01 | — | — | WO | disclosed |