Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 5/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654588 | 0.84 | MAPT (0.54) | HCAR3HTTMAPTALDH1A1MEN1 | |
| SCHEMBL15156418 | 0.83 | MAPT (0.56) | HCAR3HTTMAPTALDH1A1MEN1 | |
| Bicarbonate SCHEMBL7424111 | 0.80 | VCAM1 (0.49) | HTTMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL26343168 | 0.78 | ACMSD (0.57) | HCAR3HTTMAPTALDH1A1MEN1 | |
| Bicarbonate SCHEMBL7426714 | 0.78 | ACMSD (0.47) | HTTKMT2AACMSDTDP1HAO1 | |
| SCHEMBL8027370 | 0.76 | HCAR3 (0.62) | HCAR3HTTCDC25BMAPTALDH1A1 | |
| SCHEMBL10534783 | 0.76 | HSP90AA1 (0.55) | HTTMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL28096306 | 0.76 | HSP90AA1 (0.55) | HTTMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11213348 | 0.75 | HSP90AA1 (0.43) | HTTMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6779806 | 0.74 | HCAR3 (0.44) | HCAR3HTTCDC25BMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071669-A1 | BICYCLIC COMPOUNDS HAVING AN ANTI-THROMBITIC EFFECT | Boehringer Ingelheim Pharma KG (DE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999054313-A1 | BICYCLIC COMPOUNDS HAVING AN ANTI-THROMBITIC EFFECT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-10-28 | — | — | WO | disclosed |