Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5461521 | 0.88 | PKM (0.61) | KMT2AMAPTMEN1ALDH1A1HTT | |
| SCHEMBL6608045 | 0.84 | MAPT (0.61) | KMT2AMAPTMEN1ALDH1A1HTT | |
| SCHEMBL5624112 | 0.84 | ALDH1A1 (0.51) | KMT2AMAPTMEN1ALDH1A1MAPK1 | |
| SCHEMBL3461871 | 0.84 | HCRTR2 (0.50) | KMT2AMAPTMEN1ALDH1A1HTT | |
| SCHEMBL7423210 | 0.83 | ALDH1A1 (0.55) | ALDH1A1MAPK1NR3C1NR1I2LMNA | |
| SCHEMBL6574348 | 0.83 | MMP1 (0.52) | KMT2AMAPTMEN1ALDH1A1HTT | |
| SCHEMBL28751721 | 0.80 | ALDH1A1 (0.54) | KMT2AMAPTMEN1ALDH1A1MAPK1 | |
| SCHEMBL26247562 | 0.80 | MAPT (0.61) | KMT2AMAPTMEN1ALDH1A1HTT | |
| SCHEMBL6611414 | 0.80 | MAPT (0.61) | KMT2AMAPTMEN1ALDH1A1HTT | |
| SCHEMBL7000752 | 0.80 | KEAP1 (0.66) | KMT2AMAPTMEN1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885205-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-0885205-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5780480-A | THROMBOLYTIC AGENTS, ANTICOAGULANTS | MERCK & CO., INC. (US) | 1998-07-14 | — | — | US | disclosed |
| WO-1997031910-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-09-04 | — | — | WO | disclosed |