Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.51 |
| ▸ | CTSK | P43235 | 3/20 | 0.51 |
| ▸ | CTSL | P07711 | 2/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.51 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.45 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420947 | 0.87 | CTSK (0.45) | CTSSCTSKCTSLCTSBMMP2 | |
| SCHEMBL7420389 | 0.84 | CTSS (0.48) | CTSSCTSKCTSLCTSBMMP1 | |
| SCHEMBL7427413 | 0.84 | CTSS (0.48) | CTSSCTSKCTSLCTSBMMP1 | |
| SCHEMBL7424801 | 0.84 | CTSS (0.46) | CTSSCTSKCTSLCTSBGRIA4 | |
| SCHEMBL7425607 | 0.83 | CTSL (0.48) | CTSSCTSKCTSLCTSBMMP1 | |
| SCHEMBL7421684 | 0.81 | S1PR4 (0.40) | CTSSCTSKCTSLCTSBMMP1 | |
| SCHEMBL7419482 | 0.80 | GRN (0.49) | CTSSCTSKMMP1MMP2MMP3 | |
| SCHEMBL7418370 | 0.80 | PSEN1 (0.60) | CTSSCTSKCTSLCTSBMMP1 | |
| SCHEMBL7417901 | 0.79 | FOLH1 (0.57) | CTSSCTSKFOLH1MAPTMME | |
| SCHEMBL7378949 | 0.79 | MME (0.50) | CTSSCTSKMMP9FOLH1MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |