Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424828 | 0.80 | CYP3A4 (0.44) | KMT2ASMN1; SMN2ALDH1A1MEN1KDM4E | |
| SCHEMBL7360081 | 0.80 | RAB9A (0.46) | P2RX7KMT2AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL7363206 | 0.79 | ALDH1A1 (0.43) | P2RX7KMT2AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL7360003 | 0.78 | P2RX7 (0.61) | P2RX7HRH2HRH4 | |
| SCHEMBL9147482 | 0.77 | BCL6 (0.53) | KMT2AALDH1A1MEN1KDM4ERAB9A | |
| SCHEMBL6403636 | 0.76 | P2RX7 (0.71) | P2RX7KMT2AALDH1A1MEN1 | |
| SCHEMBL7359995 | 0.73 | P2RX7 (0.45) | P2RX7 | |
| SCHEMBL8619959 | 0.73 | P2RX7 (0.45) | P2RX7 | |
| SCHEMBL9147554 | 0.73 | HRH4 (0.43) | KMT2ASMN1; SMN2ALDH1A1MEN1KDM4E | |
| SCHEMBL8618718 | 0.73 | P2RX7 (0.45) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741708-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020579-A1 | CYANOGUANIDINES AS K-CHANNEL BLOCKERS | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-03 | — | — | WO | claimed |