Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | GRN | P28799 | 2/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424732 | 0.83 | MAPK1 (0.39) | CNR2PPARAMAPK1 | |
| SCHEMBL7422445 | 0.82 | SLC1A5 (0.40) | GRNSORT1PPARACHRM1 | |
| SCHEMBL7419478 | 0.81 | MMP2 (0.42) | APPGRNSORT1F7ADAMTS5 | |
| SCHEMBL7422595 | 0.81 | RXRA (0.40) | GRNSORT1F7ADAMTS5AOC3 | |
| SCHEMBL7429356 | 0.79 | MAPK1 (0.40) | CNR2MAPK1 | |
| SCHEMBL7427310 | 0.77 | CD274 (0.41) | APPGRNSORT1KMT2ANR4A2 | |
| SCHEMBL7419020 | 0.77 | GRN (0.38) | GRNSORT1F7ADAMTS5AOC3 | |
| SCHEMBL7378945 | 0.76 | MEN1 (0.48) | KMT2AAOC3MMP1MMP3 | |
| SCHEMBL7430634 | 0.76 | AOC3 (0.39) | GRNSORT1ADAMTS5AOC3MMP1 | |
| SCHEMBL7426730 | 0.75 | AOC3 (0.43) | KMT2APTGER4PTGER2AOC3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |