Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 4/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | OXER1 | Q8TDS5 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425567 | 0.92 | ALOX5AP (0.36) | AGTR1AGTR2ALOX5APAKR1A1AKR1B1 | |
| SCHEMBL7418814 | 0.90 | OXER1 (0.41) | SLC22A12ALOX5APOXER1PPARGPLA2G4A | |
| SCHEMBL7420228 | 0.90 | MAPT (0.38) | PPARG | |
| SCHEMBL7420795 | 0.89 | AGTR1 (0.44) | AGTR1AGTR2ALOX5APAKR1A1AKR1B1 | |
| SCHEMBL7425218 | 0.89 | MEN1 (0.42) | AGTR1AGTR2 | |
| SCHEMBL7425988 | 0.89 | AGTR1 (0.36) | AGTR1AGTR2SLC22A12ALOX5APOXER1 | |
| SCHEMBL7707845 | 0.89 | SLC22A12 (0.37) | AGTR1AGTR2SLC22A12ALOX5APOXER1 | |
| SCHEMBL7427533 | 0.87 | ALOX5AP (0.46) | SLC22A12ALOX5APPPARG | |
| SCHEMBL7707842 | 0.87 | ALOX5AP (0.45) | SLC22A12ALOX5APPPARG | |
| SCHEMBL7418558 | 0.83 | SLC22A12 (0.50) | SLC22A12OXER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-B1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-06-26 | — | — | EP | disclosed |
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |
| WO-1996032379-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-17 | — | — | WO | disclosed |