Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7425218 | 0.85 | MEN1 (0.42) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL7472730 | 0.79 | MEN1 (0.39) | MAPTSMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL7428559 | 0.78 | TP53 (0.50) | MAPTSMN1; SMN2TP53P2RX7POLB | |
| SCHEMBL7427469 | 0.76 | AGTR1 (0.40) | — | |
| SCHEMBL7418814 | 0.76 | OXER1 (0.41) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL7707845 | 0.74 | SLC22A12 (0.37) | — | |
| SCHEMBL7425988 | 0.74 | AGTR1 (0.36) | ALDH1A1HPGD | |
| SCHEMBL7427533 | 0.72 | ALOX5AP (0.46) | MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7707842 | 0.72 | ALOX5AP (0.45) | MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL7417956 | 0.71 | ALOX5AP (0.48) | MEN1KMT2AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6069156-A | Indole derivatives as cGMP-PDE inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-05-30 | — | — | US | disclosed |