SCHEMBL7425402

SCHEMBL7425402

CC(C)[C@H](COCc1cccnc1)NC(=O)C(F)(F)C(O)C(N)Cc1ccc(OCc2ccccc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 2/20 0.48
ACACB O00763 1/20 0.47
GPR132 Q9UNW8 8/20 0.46
LAP3 P28838 1/20 0.43
REN P00797 1/20 0.42
ADAMTS4 O75173 1/20 0.41
CMKLR2 P46091 1/20 0.41
CMKLR1 Q99788 1/20 0.41
MAOB P27338 1/20 0.40
MAPK1 P28482 1/20 0.40
CTSD P07339 2/20 0.40
IL1RN P18510 1/20 0.40
ERAP2 Q6P179 1/20 0.40
ERAP1 Q9NZ08 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8945507 0.93 LTA4H (0.55) LTA4HLAP3RENMAOBIL1RN
SCHEMBL8945490 0.93 LTA4H (0.55) LTA4HLAP3RENMAOBIL1RN
SCHEMBL7420013 0.88 LTA4H (0.48) LTA4HGPR132LAP3RENADAMTS4
SCHEMBL7421085 0.87 LTA4H (0.55) LTA4HLAP3RENMAOBIL1RN
SCHEMBL7418529 0.87 REN (0.47) ACACBGPR132REN
SCHEMBL7419630 0.85 CTSD (0.47) ACACBGPR132RENADAMTS4CTSD
SCHEMBL7414344 0.84 LTA4H (0.49) LTA4HLAP3RENMAOBIL1RN
SCHEMBL8945580 0.84 LTA4H (0.54) LTA4HLAP3RENMAOBCTSD
SCHEMBL7418126 0.82 LTA4H (0.53) LTA4HLAP3RENMAOB
SCHEMBL7422064 0.80 CTSD (0.47) ACACBGPR132ADAMTS4CTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0707564-B1 DIFLUORO STATONE ANALOGS MERRELL PHARMA INC (US) 2000-09-20 EP disclosed
US-6114380-A ANTIVIRAL AGENT; ADMINISTERING TO TREAT HIV INFECTION; N-(4-(N-BENZYLOXYCARBONYL-L-VALYL)AMINO-2,2-DIFLUORO-1,3-DIOXO-5-(4-(2-N -MORPHOLYL)ETHYLOXY)PHENYL-PENTYL)-O-((2-PYRIDYL)METHYL)-D-VALINOL, FOR EXAMPLE MERRELL PHARMACEUTICALS INC. (US) 2000-09-05 US disclosed
WO-1995001958-A1 DIFLUORO STATONE ANALOGS MERRELL PHARMACEUTICALS INC. (US) 1995-01-19 WO disclosed