Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | GALK1 | P51570 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | GRN | P28799 | 1/20 | 0.39 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7427316 | 0.91 | SORT1 (0.46) | MAPK1MAPTKDM4EKMT2AGRN | |
| SCHEMBL7421514 | 0.88 | ALDH1A1 (0.44) | MAPK1MAPTKDM4EGAATDP1 | |
| SCHEMBL7416089 | 0.87 | ALOX5 (0.44) | GAASORT1MME | |
| SCHEMBL7418844 | 0.83 | SORT1 (0.41) | MAPK1KDM4EKMT2AC3AR1GRN | |
| SCHEMBL7427850 | 0.82 | SORT1 (0.39) | MAPK1C3AR1GRNSORT1ALDH1A1 | |
| SCHEMBL7420893 | 0.82 | ALDH1A1 (0.41) | MAPK1MAPTKDM4EGAAAPAF1 | |
| SCHEMBL7419841 | 0.79 | KDM4E (0.44) | MAPTKDM4EGAAHPGDALDH1A1 | |
| SCHEMBL7421684 | 0.79 | S1PR4 (0.40) | MAPK1S1PR4MAPTGAASORT1 | |
| SCHEMBL7424358 | 0.78 | PSEN1 (0.49) | GRNSORT1ALDH1A1 | |
| SCHEMBL5869847 | 0.78 | SOS1 (0.50) | MAPK1S1PR4MAPTC3AR1SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |