Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | ICMT | O60725 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7416089 | 0.88 | ALOX5 (0.44) | GAA | |
| SCHEMBL7420893 | 0.87 | ALDH1A1 (0.41) | KDM4EALDH1A1MAPTPKMNPC1 | |
| SCHEMBL7421514 | 0.86 | ALDH1A1 (0.44) | KDM4EALDH1A1MAPTPKMNPC1 | |
| SCHEMBL7424358 | 0.83 | PSEN1 (0.49) | ALDH1A1MMP13 | |
| SCHEMBL7418844 | 0.82 | SORT1 (0.41) | KDM4EALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL7427316 | 0.81 | SORT1 (0.46) | KDM4EALDH1A1MAPT | |
| SCHEMBL7427850 | 0.81 | SORT1 (0.39) | ALDH1A1CTSKCTSLCTSSMMP13 | |
| SCHEMBL7421684 | 0.80 | S1PR4 (0.40) | ALDH1A1MAPTGAACTSKCTSL | |
| SCHEMBL7425626 | 0.79 | MAPK1 (0.47) | KDM4EALDH1A1MAPTNPC1HPGD | |
| SCHEMBL7422773 | 0.77 | RAB9A (0.46) | KDM4EALDH1A1MAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |