SCHEMBL74263

SCHEMBL74263

C=CC(=O)Oc1ccc(C#Cc2ccc(CCCC)cc2)cc1

nearest known ligand 0.76

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
THRB P10828 10/20 0.76
THRA P10827 8/20 0.52
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
ACACB O00763 6/20 0.46
ALDH1A1 P00352 1/20 0.43
HPGD P15428 1/20 0.43
HSD17B10 Q99714 1/20 0.43
FFAR1 O14842 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL74264 0.96 THRB (0.84) THRBTHRAMEN1KMT2AACACB
SCHEMBL14373513 0.95 THRB (0.82) THRBTHRAMEN1KMT2AACACB
SCHEMBL14373517 0.92 THRB (0.78) THRBTHRAMEN1KMT2AACACB
SCHEMBL74647 0.92 THRB (0.82) THRBTHRAKMT2AACACBALDH1A1
SCHEMBL1401854 0.91 THRB (0.91) THRBTHRAMEN1KMT2AALDH1A1
SCHEMBL14373507 0.89 THRB (0.72) THRBTHRAMEN1KMT2A
SCHEMBL14373519 0.88 THRB (0.76) THRBKMT2AACACBALDH1A1
SCHEMBL13614374 0.87 THRB (0.78) THRBTHRAMEN1KMT2AALDH1A1
SCHEMBL823056 0.87 THRB (0.83) THRBTHRAMEN1KMT2AALDH1A1
SCHEMBL11031162 0.87 THRB (1.00) THRBTHRAMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8992796-B2 Polymerizable liquid crystal composition DIC CORPORATION (JP) 2015-03-31 US disclosed
US-8992796-B2 Polymerizable liquid crystal composition DIC CORPORATION (JP) 2015-03-31 US disclosed
EP-2325168-B1 POLYMERIZABLE OPTICALLY ACTIVE IMIDE COMPOUND AND POLYMERIZABLE COMPOSITION CONTAINING THE COMPOUND ADEKA CORP (JP) 2014-03-19 EP disclosed
US-8512597-B2 Polymerizable optically active imide compound and polymerizable composition containing the compound ADEKA CORPORATION (JP) 2013-08-20 US disclosed
US-8512597-B2 Polymerizable optically active imide compound and polymerizable composition containing the compound ADEKA CORPORATION (JP) 2013-08-20 US disclosed
US-8139189-B2 Liquid crystal display having particular oblique vapor deposition-alignment layer with ferroelectric liquid crystal DAI NIPPON PRINTING CO., LTD. (JP) 2012-03-20 US disclosed
US-20120056129-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOSITION DIC CORPORATION (JP) 2012-03-08 US disclosed
US-8130358-B2 Liquid crystal display DAI NIPPON PRINTING CO., LTD. (JP) 2012-03-06 US disclosed
US-8057701-B2 Trifunctional (meth)acrylate compound and polymerizable composition containing same ADEKA CORPORATION (JP) 2011-11-15 US disclosed
US-8009266-B2 Process for producing liquid crystal display DAI NIPPON PRINTING CO., LTD. (JP) 2011-08-30 US disclosed
US-20100032621-A1 POLYMERIZABLE COMPOUNDS AND POLYMERIZABLE COMPOSITIONS ADEKA CORPORATION (JP) 2010-02-11 US disclosed
US-20100032621-A1 POLYMERIZABLE COMPOUNDS AND POLYMERIZABLE COMPOSITIONS ADEKA CORPORATION (JP) 2010-02-11 US disclosed
US-20100007832-A1 LIQUID CRYSTAL DISPLAY DAI NIPPON PRINTING CO., LTD. (JP) 2010-01-14 US disclosed
EP-2130843-A1 POLYMERIZABLE COMPOUNDS AND POLYMERIZABLE COMPOSITIONS Adeka Corporation (JP) 2009-12-09 EP disclosed
EP-2119701-A1 POLYMERIZABLE OPTICALLY-ACTIVE COMPOUND, AND POLYMERIZABLE COMPOSITION COMPRISING THE POLYMERIZABLE OPTICALLY-ACTIVE COMPOUND Adeka Corporation (JP) 2009-11-18 EP disclosed
US-7570331-B2 Liquid crystal display DAI NIPPON PRINTING CO., LTD. (JP) 2009-08-04 US disclosed
US-7499135-B2 Liquid crystal display DAI NIPPON PRINTING CO., LTD. (JP) 2009-03-03 US disclosed
US-20090050844-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOSITION DIC CORPORATION (JP) 2009-02-26 US disclosed
US-20070238026-A1 Holographic recording composition, optical recording medium and optical recording method FUJIFILM CORPORATION (JP) 2007-10-11 US disclosed
US-20070026165-A1 Liquid crystal display and manufacturing method of same DAI NIPPON PRINTING CO., LTD. (JP) 2007-02-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090050844-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOSITION H1-0, H1-4, H1-10 THRB 3657/4885THRA 2549/4885MEN1 1359/4885
US-20100032621-A1 POLYMERIZABLE COMPOUNDS AND POLYMERIZABLE COMPOSITIONS CHRM1, CHRM2, CCNE1 THRB 4880/4885THRA 4875/4885MEN1 95/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.