SCHEMBL74647

SCHEMBL74647

C=CC(=O)Oc1ccc(C#Cc2ccc(CCC)cc2)cc1

nearest known ligand 0.82

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
THRB P10828 4/20 0.82
ACACB O00763 12/20 0.48
PLA2G1B P04054 1/20 0.45
KMT2A Q03164 1/20 0.45
ATG4B Q9Y4P1 1/20 0.45
ALDH1A1 P00352 1/20 0.43
THRA P10827 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14373519 0.96 THRB (0.76) THRBACACBPLA2G1BKMT2AATG4B
SCHEMBL14373515 0.92 THRB (0.70) THRBACACBPLA2G1BKMT2AATG4B
SCHEMBL74263 0.92 THRB (0.76) THRBACACBKMT2AALDH1A1THRA
SCHEMBL4596017 0.91 THRB (1.00) THRBPLA2G1BKMT2AATG4BALDH1A1
SCHEMBL74264 0.90 THRB (0.84) THRBACACBKMT2AALDH1A1THRA
SCHEMBL7787037 0.89 THRB (0.97) THRBPLA2G1BKMT2AATG4BALDH1A1
SCHEMBL14373513 0.89 THRB (0.82) THRBACACBKMT2AALDH1A1THRA
SCHEMBL14373517 0.87 THRB (0.78) THRBACACBKMT2AALDH1A1THRA
SCHEMBL815739 0.86 THRB (0.90) THRBACACBPLA2G1BKMT2AATG4B
SCHEMBL7212815 0.86 THRB (0.90) THRBPLA2G1BKMT2AATG4BALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8992796-B2 Polymerizable liquid crystal composition DIC CORPORATION (JP) 2015-03-31 US disclosed
US-8992796-B2 Polymerizable liquid crystal composition DIC CORPORATION (JP) 2015-03-31 US disclosed
US-8168734-B2 Lateral alpha-substituted acrylate compound and polymer thereof JNC CORPORATION (JP) 2012-05-01 US disclosed
US-8139189-B2 Liquid crystal display having particular oblique vapor deposition-alignment layer with ferroelectric liquid crystal DAI NIPPON PRINTING CO., LTD. (JP) 2012-03-20 US disclosed
US-20120056129-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOSITION DIC CORPORATION (JP) 2012-03-08 US disclosed
US-8130358-B2 Liquid crystal display DAI NIPPON PRINTING CO., LTD. (JP) 2012-03-06 US disclosed
US-8094269-B2 Liquid crystal display device, manufacturing method thereof, and color filter substrate HITACHI DISPLAYS, LTD. (JP) 2012-01-10 US disclosed
US-8009266-B2 Process for producing liquid crystal display DAI NIPPON PRINTING CO., LTD. (JP) 2011-08-30 US disclosed
US-20110144293-A1 LATERAL ALPHA-SUBSTITUTED ACRYLATE COMPOUND AND POLYMER THEREOF CHISSO CORPORATION (JP) 2011-06-16 US disclosed
US-7927671-B2 Having two polymerizable groups at an end of a molecular long axis and one polymerizable group at an end of a molecular short axis; heat resistance, shrinkage, adhesive property, close adhesiveness, mechanical strength; liquid crystal display CHISSO CORPORATION (JP) 2011-04-19 US disclosed
US-20090147200-A1 VERTICAL ALIGNMENT FILM AND METHOD OF MANUFACTURING THEREOF, VERTICAL ALIGNMENT SUBSTRATE AND METHOD OF MANUFACTURING THEREOF, AND LIQUID CRYSTAL DISPLAY DEVICE SONY CORPORATION (JP) 2009-06-11 US disclosed
US-7499135-B2 Liquid crystal display DAI NIPPON PRINTING CO., LTD. (JP) 2009-03-03 US disclosed
US-20090050844-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOSITION DIC CORPORATION (JP) 2009-02-26 US disclosed
US-20090021675-A1 Liquid Crystal Display Device, Manufacturing Method Thereof, and Color Filter Substrate IPS ALPHA SUPPORT CO., LTD. (JP) 2009-01-22 US disclosed
US-20080081133-A1 Trifunctional compound, composition and polymer thereof CHISSO CORPORATION 2008-04-03 US disclosed
US-20080074588-A1 LIQUID CRYSTAL DISPLAY DEVICE AND MANUFACTURING METHOD THEREOF MAGNOLIA PURPLE CORPORATION (JP) 2008-03-27 US disclosed
US-20070238026-A1 Holographic recording composition, optical recording medium and optical recording method FUJIFILM CORPORATION (JP) 2007-10-11 US disclosed
US-20070134447-A1 Lateral a-substituted acrylate compound and polymer thereof CHISSO CORPORATION 2007-06-14 US disclosed
US-20070134440-A1 Lateral oxirane compound and polymer thereof CHISSO CORPORATION 2007-06-14 US disclosed
US-20070026165-A1 Liquid crystal display and manufacturing method of same DAI NIPPON PRINTING CO., LTD. (JP) 2007-02-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080081133-A1 Trifunctional compound, composition and polymer thereof OXER1, AFF1, OXGR1 THRB 2863/4885ACACB 1926/4885PLA2G1B 4380/4885
US-20110144293-A1 LATERAL ALPHA-SUBSTITUTED ACRYLATE COMPOUND AND POLYMER THEREOF LEF1, AFF1, CNKSR1 THRB 1814/4885ACACB 3183/4885PLA2G1B 3455/4885
US-20090050844-A1 POLYMERIZABLE LIQUID CRYSTAL COMPOSITION H1-0, H1-4, H1-10 THRB 3657/4885ACACB 4059/4885PLA2G1B 2444/4885
US-20070134447-A1 Lateral a-substituted acrylate compound and polymer thereof AFF1, CNKSR1, LEF1 THRB 3134/4885ACACB 3263/4885PLA2G1B 3609/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.