SCHEMBL7426417

SCHEMBL7426417

O=C1CCCc2sc3ccccc3c21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.40
FABP4 P15090 1/20 0.39
FABP5 Q01469 1/20 0.39
ALDH1A1 P00352 3/20 0.38
MAPT P10636 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
HSD17B10 Q99714 1/20 0.38
ALOX15 P16050 1/20 0.37
DYRK1A Q13627 1/20 0.36
LMNA P02545 2/20 0.36
POLB P06746 1/20 0.36
CYP2A6 P11509 1/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
TNKS O95271 1/20 0.36
TNKS2 Q9H2K2 1/20 0.36
MAP3K9 P80192 1/20 0.35
MAP3K11 Q16584 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17023616 0.89 GPR3 (0.43) GPR3FABP4FABP5ALDH1A1MAPT
SCHEMBL807457 0.76 MAP3K9 (0.45) GPR3ALDH1A1MAPTMEN1KMT2A
SCHEMBL15595295 0.73 DRD2 (0.49) GPR3FABP4FABP5ALDH1A1MAPT
SCHEMBL23878721 0.71 HSD17B10 (0.45) GPR3ALDH1A1MAPTNPSR1MEN1
SCHEMBL29292345 0.71 ALDH1A1 (0.44) GPR3ALDH1A1MAPTNPSR1MEN1
Hydrochloric Acid SCHEMBL5240304 0.70 MAP3K9 (0.49) GPR3ALDH1A1MAPTMEN1KMT2A
SCHEMBL13600308 0.70 GPR3 (0.52) GPR3ALDH1A1MAPTMEN1KMT2A
SCHEMBL29767754 0.69 DRD2 (0.49) GPR3ALDH1A1MAPTMEN1KMT2A
SCHEMBL450863 0.69 DRD2 (0.49) GPR3ALDH1A1MAPTMEN1KMT2A
SCHEMBL19752571 0.68 GPR3 (0.40) GPR3FABP4FABP5ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220396581-A1 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS Janssen Biopharma, Inc. (US) 2022-12-15 US disclosed
WO-2021183980-A1 SUBSTITUTED PYRIMIDINES AND TRIAZINES AS HERBICIDES FMC CORPORATION (US) 2021-09-16 WO disclosed
US-11014935-B2 Compounds for the treatment of paramyxovirus viral infections Janssen Biopharma, Inc. (US) 2021-05-25 US disclosed
US-20170283429-A1 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS Janssen Biopharma, Inc. 2017-10-05 US disclosed
US-9724351-B2 Compounds for the treatment of paramoxyvirus viral infections ALIOS BIOPHARMA, INC. (US) 2017-08-08 US disclosed
US-20150238498-A1 COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS JANSSEN PHARMACEUTICA NV (BE) 2015-08-27 US disclosed
EP-2888240-A1 COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS Alios Biopharma, Inc. (US) 2015-07-01 EP disclosed
WO-2014031784-A1 COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS ALIOS BIOPHARMA, INC. (US) 2014-02-27 WO disclosed
US-4939144-A PSYCHOLOGICAL DISORDERS; ANXIOLYTIC AND ANTIEMETIC AGENTS GLAXO GROUP LIMITED (GB) 1990-07-03 US disclosed
US-4937246-A ABSORBED EASILY FROM INTESTINES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1990-06-26 US disclosed
EP-0318235-A2 PAF antagonist, 1,4-disubstituted piperazine compounds and production thereof Takeda Chemical Industries, Ltd. (JP) 1989-05-31 EP disclosed
EP-0317088-A1 Ketone derivatives GLAXO GROUP LIMITED (GB) 1989-05-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150238498-A1 COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS SARS1, MAVS, ZC3HAV1 GPR3 3907/4885FABP4 4132/4885FABP5 2814/4885
US-20220396581-A1 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS MAVS, SARS1, ZC3HAV1 GPR3 4319/4885FABP4 4157/4885FABP5 2617/4885
US-11014935-B2 Compounds for the treatment of paramyxovirus viral infections MAVS, SARS1, ZC3HAV1 GPR3 4319/4885FABP4 4157/4885FABP5 2617/4885
US-20170283429-A1 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS MAVS, SARS1, ZC3HAV1 GPR3 4319/4885FABP4 4157/4885FABP5 2617/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.