Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7892983 | 0.90 | TSHR (0.50) | TSHRGAALMNASMN1; SMN2KMT2A | |
| SCHEMBL7893101 | 0.90 | ALDH1A1 (0.56) | TSHRGAALMNASMN1; SMN2KMT2A | |
| SCHEMBL7881483 | 0.87 | TSHR (0.47) | TSHRGAALMNASMN1; SMN2KMT2A | |
| SCHEMBL8207980 | 0.83 | GAA (0.55) | GAALMNAKMT2AMEN1HPGD | |
| SCHEMBL7890876 | 0.82 | ALDH1A1 (0.54) | TSHRGAALMNASMN1; SMN2KMT2A | |
| SCHEMBL7889273 | 0.80 | FAAH (0.48) | TSHRLMNAKMT2AALDH1A1HPGD | |
| SCHEMBL7880879 | 0.80 | NCEH1 (0.48) | TSHRSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL7881465 | 0.77 | MAPT (0.44) | TSHRGAALMNASMN1; SMN2KMT2A | |
| SCHEMBL7423152 | 0.77 | SMN1; SMN2 (0.61) | LMNASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL7886971 | 0.76 | ALDH1A1 (0.53) | TSHRGAALMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934301-B1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 2001-06-20 | — | — | EP | disclosed |
| EP-0934301-A1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GmbH (DE) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998016521-A1 | AMINOTHIOPHENE CARBOXYLIC ACID AMIDES AND THE USE THEREOF AS PHOSPHODIESTERASE INHIBITORS | MERCK PATENT GMBH (DE) | 1998-04-23 | — | — | WO | disclosed |