Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | PDE5A | O76074 | 2/20 | 0.47 |
| ▸ | APEX1 | P27695 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8212496 | 0.90 | GAA (0.56) | GAALMNAHPGDPDE5AAPEX1 | |
| SCHEMBL8210271 | 0.90 | KMT2A (0.57) | LMNAAPEX1KMT2A | |
| SCHEMBL8206426 | 0.87 | GAA (0.53) | GAALMNAHPGDPDE5AAPEX1 | |
| SCHEMBL7426581 | 0.83 | TSHR (0.49) | GAALMNAHPGDKMT2AMEN1 | |
| SCHEMBL8206949 | 0.81 | LMNA (0.57) | LMNAHPGDAPEX1KMT2A | |
| SCHEMBL7422687 | 0.79 | LMNA (0.50) | GAALMNAHPGDAPEX1KMT2A | |
| SCHEMBL8209588 | 0.79 | LMNA (0.50) | GAALMNAHPGDKMT2AMEN1 | |
| SCHEMBL17241767 | 0.79 | GAA (0.57) | GAALMNAHPGDAPEX1 | |
| SCHEMBL8292287 | 0.79 | GAA (0.57) | GAALMNAHPGDAPEX1 | |
| SCHEMBL8297189 | 0.77 | GAA (0.55) | GAALMNAHPGDAPEX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143777-A | ENZYME INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-11-07 | — | — | US | disclosed |