Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.57 |
| ▸ | MMP13 | P45452 | 7/20 | 0.57 |
| ▸ | MMP9 | P14780 | 3/20 | 0.57 |
| ▸ | MMP1 | P03956 | 1/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP14 | P50281 | 1/20 | 0.57 |
| ▸ | ME3 | Q16798 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434762 | 0.86 | MMP2 (0.55) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL6686560 | 0.77 | MMP13 (0.77) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL6685968 | 0.77 | MMP13 (0.73) | MMP2MMP13MMP9MMP1MMP3 | |
| Hydrochloric Acid SCHEMBL6687154 | 0.72 | MMP13 (0.98) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL5919633 | 0.72 | MMP13 (0.77) | MMP2MMP13MMP9MMP3MMP8 | |
| SCHEMBL7430791 | 0.70 | MMP2 (0.48) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL533096 | 0.70 | ALDH1A1 (0.62) | ME3MAPTSMN1; SMN2LMNAHSD17B10 | |
| SCHEMBL7430787 | 0.70 | MMP2 (0.49) | MMP2MMP13MMP9MMP1MMP3 | |
| SCHEMBL4141969 | 0.68 | HPGD (0.69) | ME3MAPTSMN1; SMN2LMNA | |
| Acetic Acid SCHEMBL7374818 | 0.68 | ALDH1A1 (0.55) | ME3MAPTMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |