Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.49 |
| ▸ | MMP13 | P45452 | 5/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7429528 | 0.91 | MMP2 (0.47) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7430791 | 0.81 | MMP2 (0.48) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7427208 | 0.80 | MMP3 (0.50) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL6621335 | 0.80 | MMP13 (0.55) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7424411 | 0.80 | MMP2 (0.49) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL6690406 | 0.78 | MMP13 (0.80) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7434762 | 0.74 | MMP2 (0.55) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7429534 | 0.73 | MMP13 (0.46) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL7426797 | 0.70 | MMP2 (0.57) | MMP2MMP13MMP1MMP3MMP9 | |
| SCHEMBL4035778 | 0.70 | NPSR1 (0.70) | MAPTNPSR1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |