Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 6/20 | 0.48 |
| ▸ | MMP14 | P50281 | 6/20 | 0.48 |
| ▸ | MMP8 | P22894 | 6/20 | 0.48 |
| ▸ | MMP9 | P14780 | 6/20 | 0.48 |
| ▸ | MMP13 | P45452 | 5/20 | 0.48 |
| ▸ | MMP1 | P03956 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | LIPE | Q05469 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.42 |
| ▸ | MMP10 | P09238 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424416 | 0.92 | MMP1 (0.48) | MMP3MMP14MMP8MMP9MMP13 | |
| SCHEMBL7422009 | 0.82 | MMP3 (0.69) | MMP3MMP14MMP8MMP9MMP13 | |
| SCHEMBL7427208 | 0.82 | MMP3 (0.50) | MMP3MMP14MMP8MMP9MMP13 | |
| Hydrochloric Acid SCHEMBL6694879 | 0.82 | MMP3 (0.68) | MMP3MMP14MMP8MMP9MMP13 | |
| SCHEMBL7430791 | 0.81 | MMP2 (0.48) | MMP3MMP14MMP8MMP9MMP13 | |
| Sulfuric Acid SCHEMBL7435751 | 0.81 | MMP3 (0.67) | MMP3MMP14MMP8MMP9MMP13 | |
| SCHEMBL7429534 | 0.79 | MMP13 (0.46) | MMP3MMP14MMP8MMP9MMP13 | |
| SCHEMBL6621337 | 0.78 | MMP13 (0.54) | MMP3MMP13MMP2 | |
| SCHEMBL6685529 | 0.78 | MMP13 (0.79) | MMP3MMP14MMP8MMP9MMP13 | |
| SCHEMBL6395000 | 0.74 | MMP13 (0.45) | MMP3MMP14MMP8MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |