Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 9/20 | 0.46 |
| ▸ | MMP2 | P08253 | 8/20 | 0.46 |
| ▸ | MMP9 | P14780 | 4/20 | 0.46 |
| ▸ | MMP1 | P03956 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7430791 | 0.91 | MMP2 (0.48) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL7429528 | 0.82 | MMP2 (0.47) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL6621337 | 0.79 | MMP13 (0.54) | MMP13MMP2MMP3 | |
| SCHEMBL7427210 | 0.79 | MMP3 (0.48) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL6683801 | 0.78 | MMP13 (0.75) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL7424416 | 0.78 | MMP1 (0.48) | MMP13MMP2MMP9MMP1MMP3 | |
| Hydrochloric Acid SCHEMBL5717426 | 0.73 | S1PR1 (0.41) | MAPT | |
| SCHEMBL7430787 | 0.73 | MMP2 (0.49) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL7426797 | 0.68 | MMP2 (0.57) | MMP13MMP2MMP9MMP1MMP3 | |
| SCHEMBL6690406 | 0.68 | MMP13 (0.80) | MMP13MMP2MMP9MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183239-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069821-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-11-23 | — | — | WO | disclosed |