Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428677 | 0.85 | RAB9A (0.46) | RAB9ASMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL7421943 | 0.82 | RAB9A (0.47) | RAB9ASMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL7417878 | 0.82 | RAB9A (0.46) | RAB9ASMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL7423963 | 0.79 | OPRK1 (0.48) | CTSK | |
| SCHEMBL1655299 | 0.79 | ATM (0.46) | RAB9ASMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL7421654 | 0.76 | PKM (0.45) | SMN1; SMN2NPC1PKM | |
| SCHEMBL5870299 | 0.76 | RAB9A (0.46) | RAB9ASMN1; SMN2MAPTNPC1TP53 | |
| SCHEMBL7418968 | 0.74 | CTSK (0.40) | RAB9AMAPTNPC1HSD17B10ATM | |
| SCHEMBL7422349 | 0.72 | AAK1 (0.43) | HSD17B10ALDH1A1L3MBTL1MAPK1LMNA | |
| SCHEMBL7425245 | 0.72 | HSD17B10 (0.39) | RAB9ASMN1; SMN2MAPTNPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |