Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10444288 | 0.74 | HTR1A (0.45) | HTR1AHTR1DHTR2CMEN1MAPT | |
| SCHEMBL507239 | 0.73 | HTR2A (0.39) | HTR1AHTR1DHTR2CLTA4HHCRTR2 | |
| SCHEMBL7752945 | 0.69 | HTR1A (0.58) | HTR1AHTR1DHTR2CMAOBHCRTR2 | |
| SCHEMBL14674073 | 0.65 | LTB4R (0.42) | MAOBTAAR1 | |
| SCHEMBL14673819 | 0.65 | LTB4R (0.42) | MAOBTAAR1 | |
| SCHEMBL7757639 | 0.65 | HTR2C (0.53) | HTR1AHTR1DHTR2CTAAR1 | |
| SCHEMBL14673382 | 0.65 | LTB4R (0.42) | MAOBTAAR1 | |
| SCHEMBL14673077 | 0.65 | LTB4R (0.42) | MAOBTAAR1 | |
| SCHEMBL14673750 | 0.65 | LTB4R (0.42) | MAOBTAAR1 | |
| SCHEMBL507442 | 0.64 | LTA4H (0.38) | LTA4HTAAR1CYP3A4CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | claimed |
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | disclosed |