Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | HTR2C | P28335 | 2/20 | 0.58 |
| ▸ | HTR1D | P28221 | 1/20 | 0.58 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7752947 | 0.88 | HTR1A (0.56) | HTR1AHTR2CHTR1DHCRTR2TAAR1 | |
| SCHEMBL7757639 | 0.86 | HTR2C (0.53) | HTR1AHTR2CHTR1DTAAR1SLC6A2 | |
| SCHEMBL95790 | 0.81 | HTR2C (0.61) | HTR1AHTR2CHTR1DHCRTR2SLC6A2 | |
| SCHEMBL8130244 | 0.78 | HTR1A (0.57) | HTR1AHTR2CHTR1DTAAR1TP53 | |
| SCHEMBL172889 | 0.78 | HTR1A (0.57) | HTR1AHTR2CHTR1DHCRTR2MEN1 | |
| SCHEMBL7757152 | 0.77 | MTNR1A (0.50) | HTR1AHTR2CHTR1DHCRTR2MEN1 | |
| SCHEMBL13038051 | 0.76 | HCRTR2 (0.48) | HCRTR2PARP1CYP3A4TP53 | |
| SCHEMBL22923302 | 0.76 | HCRTR2 (0.48) | HCRTR2PARP1CYP3A4TP53 | |
| SCHEMBL6215060 | 0.75 | HTR1A (0.57) | HTR1AHTR2CHTR1DHCRTR2 | |
| SCHEMBL6339887 | 0.74 | HTR1A (0.55) | HTR1AHTR2CHTR1DMAOBSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721947-B1 | Alkyl(hetero)cyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2001-03-14 | — | — | EP | disclosed |
| US-5703121-A | SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-12-30 | — | — | US | disclosed |
| EP-0721947-A1 | Alkyl(hetero)cyclic compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-07-17 | — | — | EP | disclosed |