Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.39 |
| ▸ | TTK | P33981 | 2/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 4/20 | 0.34 |
| ▸ | FLT3 | P36888 | 3/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 3/20 | 0.33 |
| ▸ | PLK4 | O00444 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777030 | 0.96 | MAP2K4 (0.41) | MAP2K4TTKPDPK1KDRKDM4E | |
| SCHEMBL7420704 | 0.85 | KDM4E (0.39) | TTKPDPK1KDRKDM4EHIF1A | |
| SCHEMBL2723270 | 0.76 | MAP2K4 (0.49) | MAP2K4TTKKDRKDM4EHIF1A | |
| SCHEMBL8877409 | 0.74 | MAP2K4 (0.44) | MAP2K4TTKPDPK1KDRKDM4E | |
| SCHEMBL1648452 | 0.74 | MAP2K4 (0.44) | MAP2K4TTKPDPK1KDRKDM4E | |
| SCHEMBL16252836 | 0.73 | MAP2K4 (0.43) | MAP2K4TTKPDPK1KDRKDM4E | |
| SCHEMBL2021782 | 0.72 | KDR (0.52) | MAP2K4TTKPDPK1KDRKDM4E | |
| SCHEMBL16475286 | 0.72 | PDPK1 (0.56) | PDPK1KDRKDM4ECDK2FLT3 | |
| SCHEMBL25696142 | 0.71 | MAP2K4 (0.35) | MAP2K4TTKKDM4EHIF1AMAPK1 | |
| Oxalic Acid SCHEMBL6033591 | 0.71 | FLT3 (0.58) | MAP2K4PDPK1KDM4EHIF1AYTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999017772-A1 | 5HT4 AGONISTS AND ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |