Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.46 |
| ▸ | CTSL | P07711 | 5/20 | 0.46 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | PRTN3 | P24158 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7399913 | 0.85 | CTSS (0.52) | CTSSCTSLCTSKPRTN3ELANE | |
| SCHEMBL7429348 | 0.85 | CTSS (0.52) | CTSSCTSLCTSKPRTN3ELANE | |
| SCHEMBL5704553 | 0.84 | CTSL (0.53) | CTSSCTSLCTSKPRTN3ELANE | |
| SCHEMBL7438056 | 0.83 | ELANE (0.48) | CTSSCTSLCTSKPRTN3ELANE | |
| SCHEMBL10432161 | 0.80 | CTSK (0.48) | CTSSCTSLCTSKPRTN3ELANE | |
| SCHEMBL10445815 | 0.79 | CTSS (0.47) | CTSSCTSLCTSKPRTN3SYK | |
| SCHEMBL12906609 | 0.78 | ATM (0.61) | CTSSCTSLCTSKPRTN3ELANE | |
| SCHEMBL10432394 | 0.78 | CTSK (0.46) | CTSSCTSLCTSKPRTN3SYK | |
| SCHEMBL7433848 | 0.77 | SYK (0.56) | CTSSCTSLCTSKPRTN3SYK | |
| SCHEMBL16847629 | 0.76 | CTSL (0.52) | CTSSCTSLCTSKPRTN3ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397427-B1 | Fluoro-amide derivatives having human leucocyte elastase inhibiting activity | ZENECA INC (US) | 1994-05-04 | — | — | EP | disclosed |
| US-5270301-A | Fluoro-amide derivatives | ICI AMERICAS INC. (US) | 1993-12-14 | — | — | US | disclosed |
| EP-0397427-A1 | Fluoro-amide derivatives having human leucocyte elastase inhibiting activity | ZENECA INC. (US) | 1990-11-14 | — | — | EP | disclosed |