Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5215499 | 0.96 | RIPK1 (0.38) | RIPK1OPRM1OPRD1MAPTFOLH1 | |
| Trifluoroacetic Acid SCHEMBL8041708 | 0.88 | RIPK1 (0.37) | RIPK1OPRM1OPRD1ALDH1A1ROCK1 | |
| Trifluoroacetic Acid SCHEMBL7433118 | 0.87 | RIPK1 (0.39) | RIPK1ALDH1A1ROCK1F2F10 | |
| Trifluoroacetic Acid SCHEMBL5208180 | 0.87 | RIPK1 (0.42) | RIPK1MAPTFOLH1ALDH1A1RAB9A | |
| Trifluoroacetic Acid SCHEMBL5212450 | 0.87 | RIPK1 (0.39) | RIPK1OPRM1OPRD1MAPTFOLH1 | |
| Trifluoroacetic Acid SCHEMBL7425564 | 0.86 | RIPK1 (0.36) | RIPK1OPRM1OPRD1ALDH1A1ROCK1 | |
| SCHEMBL7427969 | 0.86 | ALDH1A1 (0.46) | RIPK1OPRM1OPRD1MAPTALDH1A1 | |
| SCHEMBL7428011 | 0.86 | ALDH1A1 (0.39) | RIPK1OPRM1OPRD1MAPTALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5210860 | 0.86 | RIPK1 (0.42) | RIPK1MAPTFOLH1ALDH1A1RAB9A | |
| Trifluoroacetic Acid SCHEMBL7432346 | 0.85 | RIPK1 (0.37) | RIPK1OPRM1OPRD1ALDH1A1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192135-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076970-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |