Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | NPY2R | P49146 | 2/20 | 0.33 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5212782 | 0.96 | RIPK1 (0.36) | RIPK1OPRM1OPRD1OPRK1NPY2R | |
| Trifluoroacetic Acid SCHEMBL8041708 | 0.89 | RIPK1 (0.37) | RIPK1OPRM1OPRD1OPRK1TPSAB1 | |
| Trifluoroacetic Acid SCHEMBL5210137 | 0.89 | RIPK1 (0.37) | RIPK1OPRM1OPRD1OPRK1TPSAB1 | |
| Trifluoroacetic Acid SCHEMBL5209724 | 0.88 | RIPK1 (0.35) | RIPK1OPRM1OPRD1OPRK1TPSAB1 | |
| SCHEMBL7434744 | 0.88 | OPRD1 (0.36) | RIPK1OPRM1OPRD1OPRK1NPY2R | |
| Trifluoroacetic Acid SCHEMBL5214210 | 0.88 | ROCK1 (0.40) | RIPK1NPY2RTPSAB1ROCK1TP53 | |
| Trifluoroacetic Acid SCHEMBL7421783 | 0.88 | OPRM1 (0.34) | RIPK1OPRM1OPRD1OPRK1NPY2R | |
| Trifluoroacetic Acid SCHEMBL7433118 | 0.86 | RIPK1 (0.39) | RIPK1NPY2RTPSAB1ROCK1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL7430442 | 0.86 | RIPK1 (0.38) | RIPK1OPRM1OPRD1OPRK1ROCK1 | |
| Trifluoroacetic Acid SCHEMBL5211441 | 0.86 | RIPK1 (0.38) | RIPK1OPRM1OPRD1OPRK1TPSAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1192135-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076970-A2 | SERINE PROTEASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-12-21 | — | — | WO | disclosed |