Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438464 | 0.87 | MAPT (0.54) | LTA4HMAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7433530 | 0.86 | RAB9A (0.49) | LTA4HMAPTAMY1ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7430029 | 0.86 | ALDH1A1 (0.52) | MAPTSMN1; SMN2ALDH1A1TDP1LMNA | |
| SCHEMBL7438575 | 0.86 | RAB9A (0.50) | LTA4HMAPTAMY1ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7441613 | 0.85 | MAPT (0.50) | MAPTAMY1ASMN1; SMN2ALDH1A1ALOX15 | |
| SCHEMBL7444812 | 0.82 | HDAC1 (0.49) | LTA4HMAPTALDH1A1LMNAHTT | |
| SCHEMBL7435763 | 0.82 | MAPT (0.55) | MAPTSMN1; SMN2ALDH1A1GAAMEN1 | |
| SCHEMBL7436552 | 0.79 | PTGS2 (0.45) | MAPTSMN1; SMN2ALDH1A1USP2LMNA | |
| SCHEMBL7428965 | 0.79 | RAB9A (0.55) | MAPTSMN1; SMN2ALDH1A1LMNAGAA | |
| SCHEMBL7434491 | 0.79 | ABL1 (0.51) | MAPTLMNAGAATHRBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |