Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MPL | P40238 | 1/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433530 | 0.84 | RAB9A (0.49) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL7437048 | 0.82 | ATP4A (0.51) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL7434491 | 0.80 | ABL1 (0.51) | MEN1KMT2ANPC1RAB9AMAPT | |
| SCHEMBL7428965 | 0.80 | RAB9A (0.55) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL434333 | 0.80 | MEN1 (0.55) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL7438464 | 0.79 | MAPT (0.54) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL7430766 | 0.79 | LTA4H (0.53) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL7430029 | 0.78 | ALDH1A1 (0.52) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL7438575 | 0.78 | RAB9A (0.50) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL7434680 | 0.78 | GAA (0.62) | MEN1KMT2ANPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |