Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7438464 | 0.86 | MAPT (0.54) | RAB9ANPC1MAPTALDH1A1MEN1 | |
| SCHEMBL7430766 | 0.86 | LTA4H (0.53) | RAB9ANPC1MAPTALDH1A1ALOX5 | |
| SCHEMBL7429950 | 0.84 | ALOX5 (0.39) | RAB9ANPC1MAPTALDH1A1ABL1 | |
| SCHEMBL7430029 | 0.84 | ALDH1A1 (0.52) | RAB9ANPC1MAPTALDH1A1ALOX5 | |
| SCHEMBL7433530 | 0.84 | RAB9A (0.49) | RAB9ANPC1MAPTALDH1A1ALOX5 | |
| SCHEMBL7441613 | 0.84 | MAPT (0.50) | RAB9ANPC1MAPTALDH1A1ALOX5 | |
| SCHEMBL7434491 | 0.84 | ABL1 (0.51) | RAB9ANPC1MAPTABL1ALOX5 | |
| SCHEMBL7437716 | 0.82 | ABL1 (0.52) | RAB9ANPC1MAPTABL1MEN1 | |
| SCHEMBL7444812 | 0.81 | HDAC1 (0.49) | MAPTALDH1A1ALOX5MEN1KMT2A | |
| SCHEMBL7435763 | 0.81 | MAPT (0.55) | RAB9ANPC1MAPTALDH1A1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |