Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.46 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7436954 | 0.83 | PLOD2 (0.53) | PLOD2THRBPLOD3PLOD1KMT2A | |
| SCHEMBL9685598 | 0.83 | ALDH1A1 (0.52) | KMT2AMEN1ALDH1A1LMNANPC1 | |
| SCHEMBL7433203 | 0.82 | PLOD2 (0.51) | PLOD2THRBPLOD3PLOD1KMT2A | |
| SCHEMBL14073817 | 0.81 | PLOD2 (0.59) | PLOD2THRBPLOD3PLOD1KMT2A | |
| Hydrochloric Acid SCHEMBL7441292 | 0.79 | PLOD2 (0.48) | PLOD2THRBPLOD3PLOD1KMT2A | |
| SCHEMBL7443990 | 0.78 | PLOD2 (0.57) | PLOD2THRBPLOD3PLOD1KMT2A | |
| SCHEMBL27374976 | 0.77 | PLOD2 (0.49) | PLOD2THRBPLOD3PLOD1ALDH1A1 | |
| SCHEMBL9565319 | 0.77 | PLOD2 (0.46) | PLOD2THRBPLOD3PLOD1KMT2A | |
| SCHEMBL15973481 | 0.76 | PLOD2 (0.67) | PLOD2THRBPLOD3PLOD1KMT2A | |
| SCHEMBL5113226 | 0.76 | ALDH1A1 (0.52) | PLOD2THRBPLOD3PLOD1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278161-A | Racemic mixtures | HOFFMANN-LA ROCHE INC. (US) | 1994-01-11 | — | — | US | disclosed |
| EP-0464572-A2 | Aminoacid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-01-08 | — | — | EP | disclosed |