Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.42 |
| ▸ | DRD1 | P21728 | 4/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447925 | 0.85 | ALDH1A1 (0.40) | DRD2DRD1DRD4DRD3HTR1A | |
| SCHEMBL7441864 | 0.82 | DRD2 (0.48) | DRD2DRD3HTR7 | |
| SCHEMBL8691953 | 0.81 | DRD3 (0.42) | DRD2DRD1DRD4DRD3HTR1A | |
| SCHEMBL7443025 | 0.81 | DRD3 (0.42) | DRD2DRD1DRD4DRD3HTR1A | |
| SCHEMBL7432736 | 0.79 | DRD3 (0.57) | DRD2DRD1DRD4DRD3HTR1A | |
| SCHEMBL7433347 | 0.79 | PNMT (0.47) | — | |
| SCHEMBL12640603 | 0.78 | HTR1A (0.43) | DRD2DRD3HTR1AHTR7 | |
| SCHEMBL8317710 | 0.76 | VCAM1 (0.37) | DRD2DRD1HTR1A | |
| SCHEMBL8631076 | 0.76 | DRD2 (0.36) | DRD2DRD1HTR1A | |
| SCHEMBL8311336 | 0.75 | HTR2A (0.43) | DRD2DRD3HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |