Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.43 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.39 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.39 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.39 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 4/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL7442108 | 0.79 | SIGMAR1 (0.39) | DRD3DRD2HTR2AADRA2CSIGMAR1 | |
| SCHEMBL7449945 | 0.75 | NPC1 (0.56) | RAB9ANPC1HTR7L3MBTL1TMEM97 | |
| Hydrochloric Acid SCHEMBL467094 | 0.74 | NPC1 (0.54) | RAB9ANPC1HTR7L3MBTL1TMEM97 | |
| Hydrochloric Acid SCHEMBL7449337 | 0.73 | TMEM97 (0.62) | RAB9ANPC1HTR7L3MBTL1TMEM97 | |
| SCHEMBL3822016 | 0.72 | NPC1 (0.69) | RAB9ANPC1HTR7HTR1ADRD3 | |
| SCHEMBL11982908 | 0.71 | TMEM97 (0.67) | RAB9ANPC1HTR7L3MBTL1TMEM97 | |
| SCHEMBL6701558 | 0.67 | L3MBTL1 (0.71) | RAB9ANPC1HTR7HTR1ADRD3 | |
| SCHEMBL9680520 | 0.67 | NPC1 (0.91) | RAB9ANPC1HTR7HTR1ADRD3 | |
| SCHEMBL15988866 | 0.66 | CTNNB1 (0.71) | RAB9ANPC1HTR7HTR1ADRD3 | |
| SCHEMBL4897835 | 0.66 | NPC1 (0.62) | RAB9ANPC1HTR7SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5561135-A | PSYCHOLOGICAL DISORDERS | FERRER INTERNACIONAL, S.A. (ES) | 1996-10-01 | — | — | US | disclosed |
| WO-1995003270-A1 | NEW N,N,N',N'-TETRASUBSTITUTED-1,2-ETHANEDIAMINE DERIVATIVE COMPOUNDS | FERRER INTERNACIONAL, S.A. (ES) | 1995-02-02 | — | — | WO | disclosed |