Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19881221 | 0.81 | DGAT1 (0.33) | DGAT1 | |
| SCHEMBL28405499 | 0.78 | CA1 (0.38) | DGAT1LMNAFDPSKDM4E | |
| SCHEMBL22622717 | 0.77 | DGAT1 (0.33) | DGAT1 | |
| SCHEMBL19881230 | 0.77 | ALDH1A1 (0.38) | LMNA | |
| SCHEMBL1555747 | 0.76 | DGAT1 (0.39) | DGAT1LMNAADRB3FDPSPDE4D | |
| SCHEMBL888296 | 0.74 | DGAT1 (0.38) | DGAT1 | |
| Hydrochloric Acid SCHEMBL4316792 | 0.74 | DGAT1 (0.38) | DGAT1LMNAADRB3FDPSPDE4D | |
| SCHEMBL31752 | 0.74 | DGAT1 (0.38) | DGAT1 | |
| Ethylenediamine SCHEMBL27703572 | 0.73 | DGAT1 (0.41) | DGAT1LMNAKDM4E | |
| SCHEMBL8629503 | 0.71 | LMNA (0.36) | DGAT1LMNAADRB3FDPSPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6066666-A | OPTIONALLY N-SUBSTITUTED 3-MONO- AND DI-SUBSTITUTED 2-PYRROLIDINONES AND THIOLACTAM ANALOGS; TREAT SEIZURES, ANXIETY, AND ENHANCING 4-AMINOBUTYRIC ACID (GABA)-INDUCED CHLORIDE CURRENTS AT GABA RECEPTOR/IONOPHORE COMPLEX | WASHINGTON UNIVERSITY (US) | 2000-05-23 | — | — | US | disclosed |
| US-5776959-A | Anticonvulsant and anxiolytic lactam and thiolactam derivatives | WASHINGTON UNIVERSITY (US) | 1998-07-07 | — | — | US | disclosed |