Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.74 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.66 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10438662 | 0.94 | LTA4H (0.72) | LTA4HEPHX2LMNACYP1A2PTGS1 | |
| SCHEMBL9453028 | 0.93 | LTA4H (0.70) | LTA4HEPHX2LMNACYP1A2PTGS1 | |
| SCHEMBL16705571 | 0.93 | LTA4H (0.70) | LTA4HEPHX2LMNACYP1A2PTGS1 | |
| SCHEMBL9451327 | 0.90 | ALDH1A1 (0.69) | LTA4HEPHX2LMNACYP1A2PTGS1 | |
| SCHEMBL4819108 | 0.87 | ALDH1A1 (0.64) | LTA4HEPHX2LMNACYP1A2PTGS1 | |
| SCHEMBL7036584 | 0.86 | MGLL (0.67) | LTA4HEPHX2LMNACYP1A2PTGS1 | |
| SCHEMBL9808056 | 0.86 | LMNA (0.72) | LTA4HLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL1563277 | 0.85 | LTA4H (1.00) | LTA4HEPHX2LMNACYP1A2PTGS1 | |
| SCHEMBL29045776 | 0.84 | LMNA (0.59) | LTA4HEPHX2LMNACYP1A2PTGS1 | |
| SCHEMBL18429764 | 0.84 | LMNA (0.59) | LTA4HEPHX2LMNACYP1A2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016885-A2 | COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE | ARTESIAN THERAPEUTICS, INC. (US) | 2005-02-24 | — | — | WO | disclosed |
| CN-1455771-A | Cyclic amine phenyl Beta-3 adrenergic receptor agonists | WYETH LTD (US) | 2003-11-12 | — | — | CN | disclosed |
| EP-0724578-A1 | AMINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011240-A1 | AMINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-04-27 | — | — | WO | disclosed |