Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KDM4A | O75164 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28279066 | 0.85 | KDM4E (0.46) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 | |
| SCHEMBL7430168 | 0.84 | KDM4E (0.53) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 | |
| SCHEMBL7435991 | 0.82 | PDE3B (0.45) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 | |
| SCHEMBL6274459 | 0.79 | KDM4E (0.44) | KDM4EL3MBTL1RAB9ABRAFMAPT | |
| SCHEMBL6274454 | 0.78 | YTHDC1 (0.43) | KDM4EL3MBTL1RAB9AKDM4AEGLN1 | |
| SCHEMBL27626910 | 0.77 | TTR (0.51) | KDM4EL3MBTL1CDK2BRAFHSD17B10 | |
| SCHEMBL9849262 | 0.77 | L3MBTL1 (0.39) | KDM4EL3MBTL1RAB9ABRAFLIMK1 | |
| SCHEMBL30452318 | 0.75 | EGLN2 (0.51) | KDM4EL3MBTL1RAB9AMAPTTSHR | |
| SCHEMBL324349 | 0.75 | EGLN2 (0.51) | KDM4EL3MBTL1RAB9AMAPTTSHR | |
| SCHEMBL9849287 | 0.74 | PLAU (0.40) | KDM4EL3MBTL1BRAFCLK2LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0435235-B1 | Isoquinoline derivatives and salts thereof as protease inhibitors. | SNOW BRAND MILK PRODUCTS CO LTD (JP) | 1995-03-08 | — | — | EP | disclosed |
| US-5116985-A | Protease Inhibitors, Antitrypsin Agents | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| EP-0435235-A1 | Isoquinoline derivatives and salts thereof as protease inhibitors. | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1991-07-03 | — | — | EP | disclosed |