Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 3/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.36 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433788 | 0.79 | KDM4E (0.54) | KDM4ELMNAMAPTTP53TSHR | |
| SCHEMBL1503132 | 0.79 | KDM4E (0.49) | KDM4ELMNAMAPTTSHRL3MBTL1 | |
| SCHEMBL9849262 | 0.74 | L3MBTL1 (0.39) | KDM4EL3MBTL1NPC1RAB9ABRAF | |
| SCHEMBL27626910 | 0.74 | TTR (0.51) | KDM4EL3MBTL1CYP1A2KMT2AMEN1 | |
| SCHEMBL9849287 | 0.72 | PLAU (0.40) | KDM4EL3MBTL1KMT2AMEN1BRAF | |
| SCHEMBL6989543 | 0.72 | LMNA (0.50) | KDM4ELMNAMAPTTP53TSHR | |
| SCHEMBL111310 | 0.72 | CNR2 (0.53) | KDM4ELMNAMAPTTP53TSHR | |
| SCHEMBL29358323 | 0.72 | CNR2 (0.53) | KDM4ELMNAMAPTTP53TSHR | |
| SCHEMBL9849291 | 0.71 | PLAU (0.39) | KDM4EL3MBTL1KMT2AMEN1BRAF | |
| SCHEMBL3034972 | 0.71 | APOBEC3G (0.48) | KDM4ELMNAMAPTTP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121094-A1 | PIPERAZINE AND PIPERIDINE DERIVATIVES AS ANTI-HIV-AGENTS | PFIZER LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |