Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.34 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.34 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.34 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433788 | 0.77 | KDM4E (0.54) | L3MBTL1KDM4ELCKBTKMAP2K3 | |
| SCHEMBL4388890 | 0.75 | PTK2B (0.42) | L3MBTL1KDM4ENPC1POLBPTK2B | |
| SCHEMBL29757404 | 0.75 | PTK2B (0.42) | L3MBTL1KDM4ENPC1POLBPTK2B | |
| SCHEMBL6274459 | 0.74 | KDM4E (0.44) | L3MBTL1KDM4ELCKBTKMAP2K3 | |
| SCHEMBL27626910 | 0.72 | TTR (0.51) | L3MBTL1KDM4EBRAFPOLBALDH1A1 | |
| SCHEMBL9849240 | 0.72 | POLB (0.39) | KDM4ENPC1POLBPTK2BELANE | |
| SCHEMBL9849287 | 0.70 | PLAU (0.40) | L3MBTL1KDM4ELCKBTKMAP2K3 | |
| SCHEMBL29358323 | 0.69 | CNR2 (0.53) | KDM4ELCKBTKMAP2K3MAP2K6 | |
| SCHEMBL111310 | 0.69 | CNR2 (0.53) | KDM4ELCKBTKMAP2K3MAP2K6 | |
| SCHEMBL9849291 | 0.69 | PLAU (0.39) | L3MBTL1KDM4ELCKBTKMAP2K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |